Dept. of Neuroscience & Regenerative Medicine
The Goldstein Lab
1201 Goss Lane - GE2017Augusta UniversityAugusta, GA 30912
Phone: (706) 723-4391
Email: egoldstein@augusta.edu
Histones
DNA wrapped around histones that can change DNA expression by covelant modifications
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Our Team
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.665409/full
Frontiers
Nature Communications
Forbes, T.A., Goldstein, E.Z., Dupree, J.L. et al. Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery. Nat Commun 11, 964 (2020). https://doi.org/10.1038/s41467-020-14762-7
The white matter producing cells of the central nervous system
Oligodendrocytes
Over ten percent of babies are born preterm. Often, the lungs of preterm infants are not fully developed, leading to brain hypoxia.
Diffuse White Matter
The
Goldstein
Lab
Our Mission
Brain damage induced by premature birth is the leading cause of neurodevelopmental disabilities. Research in the Goldstein lab investigates the pathogenesis and repair of diffuse white matter injury – the most common neuropathological outcome of premature birth. Clinical studies demonstrate that environmental factors benefit recovery from white matter injury, however specific mechanisms driving progression and recovery are not well understood. Previous work showed that recovery in an enriched environment ameliorates developmental brain injury and promotes functional recovery. The current focus in the lab is to identify how environmental stimuli direct cell and molecular changes in the brain. Using a mouse model of diffuse white matter injury or postmortem preterm infant brain samples, we are investigating the role of histone modifications in white matter injury. Our studies will inform the quest to develop improved therapeutic options for babies born preterm.
Recent Publications
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Current projects:
Jasmine Baidoo
Aeris Xiong
Raaga Kottapally
Isaac Bloom
Christina Yi
Oviya
Sinthanai-Selvan
Simran Patki
Cole Jordan
Dr. Goldstein
Principal Investigator